… development and carcinogenesis. In this review, we summarize the recent studies in DNA
methylation … their potential role in gene silencing in development and disease. Although the …

… two developmental periods, primordial germ cell (PGC) specification and the early embryo,
in which DNA methylation … principles of DNA methylation in mammalian development and set …

… DNA Methylation in the Early Embryo In order to understand how DNA methylation may be
involved in the regulation of gene expression during normal development, it was important to …

… DNA methylation is an important modification in development. Though developmental
changes in DNA methylation … as in pluripotent genes, developmental genes, and tissue specific …

… DNA methylation is involved in embryo development. … develop to term and die at the 5 to
20 somite stage corresponding to the level of the enzyme. In the mouse, dramatic methylation …

… development in the human brain than was previously available. Although previous efforts
to comprehensively measure DNA methylation … features of brain development 16 , our study …

… , and that DNA methylation has regulatory roles in … DNA methylation during development
are a dynamic, widespread, and tissue-specific process involving both DNA methylation …

… plays a critical role in silencing specific genes during development and cell differentiation.
The intrinsic mutagenicity of 5-mC, activation of proto-oncogenes through hypomethylation, …

… In this regard, the details of DNA methylation … in early development and germ cell differentiation
in humans will influence our understanding of the potential impact of DNA methylation in …

… of methylation at distinct residues of the N-terminal tails of histone H3 and H4. This review
describes the role of the DNA methylation-… remodelling activities) in animal development. …